by vampyri_lestat explains how to turn off the autosave function. I did notice an increase in load times as I progressed in the game, too. The Planet Vampire Bloodlines tech support
may have some help for your problems.
I've had such a good time playing this game I wondered if anyone might be interested in the PnP version. I'm not sure how feasible it is to do online or in the chatbox/IRC, but it might be doable.