I must be lucky, then. I've just installed Grim Fandango on Vista and it seems
to be working fine. I had to change the compatibility mode to Windows 98/ME, before that the sound would suddenly stop and not come back, but now the only problem I have is a little graphics bug with Manny's shadow, which doesn't affect the actual gameplay. Although I'm only up to the Petrified Forest so far, so we'll see...
I was really surprised when I installed it and it actually ran
. I've tried running Monkey Island 1 & 2 on Vista but those won't work at all.