[QUOTE=Jona]I suggest you try my homemade modified version ... included is the patched files, and multithreadprocessing is already disabled in the exe, so you shouldn't have any problems with that... plus some minor tweaks, I've run this just fine under both Vista 32 and 64.
Just copy the files to your install directory (usually \Program Files\LucasArts\Grim\) and run grimfandango.exe.
Thanks JONA! Ur homebrew was delicious!! It works like a charm! This thread should be sticked for working Grim in vista. THanks again!