To everyone having problems with KSE using Vista, I'm afraid I can't help you much at this time since Vista has some strict security issues that I'm not an expert on. I do know that the Program Files folder is generally off-limits to normal users attempting to modify files so KSE should always be Run As Administrator. Other things include read only access to savegames -- you may need to change all the save game folders to not be Read Only.
I would encourage others who have Vista and have used KSE successfully to offer their advice to fellow Vista users in this thread.
From now on, please say what operating system you have when you have KSE problems to report. And please also check this thread
first before posting. Thanks!